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Adverse reaction vs side effect diflucan12/24/2023 ![]() ![]() Other antifungals are not capable of entering such sequestered areas of the body. Another reason to choose fluconazole is ability to penetrate the blood-brain barrier or eye, places where other antifungals cannot go, in order to address a neurologic or ophthalmic infection. Fluconazole is not associated with hormone interference and has less trouble with upset stomach reactions. One reason is to avoid side effects, especially with long term use. There are three reasons for choosing fluconazole over other antifungal agents. Fluconazole represent yet another generation allowing excellent penetration of the blood/brain barrier, allowing neurologic fungal diseases to be treatable, while in the past they were not. Its potential for side effects is far lower and, recently, generic medications have made fluconazole readily affordable. Fluconazole was developed in answer to these concerns. There were problems with nausea, liver toxicity, and feminization of male patients. Ketoconazole was the first such oral antifungal drug but it had room for improvement regarding its side effect potential. Further, the toxicity profiles of the newer oral drugs represent vast improvement over those of the injectables. With oral treatment available, human patients no longer require hospitalization several days per week for intravenous treatment of their disease a more normal and productive lifestyle is now possible. The development of oral medications to be used in the treatment of invasive fungal infections has represented an immense medical breakthrough. ![]()
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